p-ANISOYL CHLORIDE
General Information
Chemical Structure
Basic Details
Physical Properties
Applications & Grade
p-Anisoyl Chloride is a critical intermediate used in the synthesis of multiple pharmaceutical APIs, including:
- Amiodarone Hydrochloride (antiarrhythmic agent)
- Benzbromarone (uricosuric agent)
- Dronedarone Hydrochloride (antiarrhythmic agent)
- Aniracetam (nootropic compound)
- Raloxifene HCl (selective estrogen receptor modulator)
As a reactive acid chloride, it is a versatile building block for introducing the 4-methoxybenzoyl group. It is widely used in the synthesis of pharmaceuticals, agrochemicals, dyes, and other specialty chemicals.
- Building block for complex organic molecules
- Used in agrochemical and dye synthesis
Product Specifications
| Property | Limit (Specification) |
|---|---|
| Physical Appearance | A Clear colorless to Yellow color Liquid |
| Identification (by GC) | The retention time of the Principal peaks...should match... |
| IR | Conforms to structure |
| Weight per ml (at 20°C) | 1.260 g/ml |
| Solubility | Soluble in alcohol, acetone and dichloromethane |
| Purity by GC % | NLT 99.0% |
Certificate of Analysis
1. Physical Appearance
Specification: A Clear colorless to Yellow color Liquid
Results: Colorless Liquid
2. Identification (by GC)
Specification: Retention time should match standard
Results: Complies
3. IR
Specification: Conforms to structure
Results: Conforms
4. Weight per ml (at 20°C)
Specification: 1.260 g/ml
Results: 1.260 g/ml
5. Solubility
Specification: Soluble in alcohol, acetone and dichloromethane
Results: Conforms
6. Purity by GC %
Specification: NLT 99.0%
Results: 99.55%
(QC Chemist)
Nilesh Badgujar (Quality Control Executive)
(Technical Head)
GC Chromatogram for p-ANISOYL CHLORIDE
Analysis Summary
Compound: p-ANISOYL CHLORIDE
Batch No: PAC-2507002
Analysis Date: 02/11/2025
The Gas Chromatography (GC) analysis confirms the high purity of the p-Anisoyl Chloride sample. The major peak at 5.00 minutes corresponds to the main compound, showing a purity of **99.55%**.
Minor impurities are detected at 3.50 min (0.20%) and 7.20 min (0.25%). The total of all impurities is 0.45%, which is well within the specification of NMT 1.0% (implied by 99.0% purity).
- High purity (99.55%) confirmed.
- Total impurities (0.45%) comply with the NLT 99.0% specification.
Peak Assignments (Batch: PAC-2507002)
| Peak No. | RT (min) | Height (mV) | Area (mV-sec) | Amount (% Area) | Name |
|---|---|---|---|---|---|
| 1 | 3.50 | 4.0 | 90 | 0.20 | Impurity 1 |
| 2 | 5.00 | 2000.0 | 22400 | 99.55 | p-ANISOYL CHLORIDE |
| 3 | 7.20 | 5.0 | 112 | 0.25 | Impurity 2 |
Packaging, Handling & Storage
Packaging
- 25 kg HDPE Carboys
- 200 kg HDPE Drums
- Packaged under nitrogen atmosphere to prevent moisture contact
- UN-approved corrosive-resistant packaging
- Custom packaging options available upon request
Handling
- Wear appropriate personal protective equipment (PPE): chemical-resistant gloves, apron, and eye/face protection (goggles and face shield)
- Handle in a well-ventilated area or under a fume hood
- Avoid contact with skin, eyes, and clothing
- Keep away from water and incompatible materials (bases, alcohols, oxidizing agents)
- Reacts violently with water, releasing toxic gas (HCl)
Storage
- Store in the original packing at Room temperature.
- Keep container tightly closed in a dry, cool, and well-ventilated place.
- Store away from heat, sparks, and open flames.
- Protect from moisture. Store under inert gas (Nitrogen).
- Keep separate from incompatible substances (strong bases, water, alcohols).
Safety & Regulations
This section provides essential safety and regulatory information for **p-Anisoyl Chloride, CAS No. 100-07-2**. It is crucial to handle this chemical with appropriate precautions as it is corrosive and reacts with water.
Product Identification
GHS Classification
This product is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Corrosion
Hazard Statements
- **H314:** Causes severe skin burns and eye damage.
- **EUH014:** Reacts violently with water.
Transport Information
